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Activated from the antibiotic rifampicin and many plant metabolites, which include hyperforin, guggulipid, colupulone, and isoflavones. Reaction to particular ligands is species-precise. Activated by naturally transpiring steroids, like pregnenolone and progesterone. Binds to your reaction component in the promoters on the CYP3A4 and ABCB1/MDR1 gen